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Chromogenix

Antithrombin 10x10IU:

Catalog # 82072039
Packaging Vial/10IU
Method Chromogenic
Type Bioreagent
Use For Research Use Only
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Chromogenix Antithrombin 10IU is for the determination of Heparin in plasma. Antithrombin in conjunction with heparine like substances is a potent inhibitor of thrombin, factor Xa, factor Xla and factor lXa. Antithrombin is prepared from human plasma and purified by affinity chromatography with an Heparine Sepharose gel according to the protocol of Miller-Andersson et al.

Lyophilized powder prepared from human plasma after affinity chromatography on heparin-Sepharose gel. Contains human albumin as a stabilizer.

  • Lyophilized human Antithrombin 10 lU ± 1
  • Albumin 12 mg
  • Sodium Chloride 9 mg

The lyophilized powder is stable at 2-8°C until the expiry date printed on the label. The reconstituted Antithrombin is stable for 1 month at 2-8°C or 6 months at -20°C when used for the determination of Heparin, according to the test conditions of Chromogenix Coatest® Heparin.

Specific Activity:Above 6 IU/mg Antithrombin.

Note:This preparation is not a standard.

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Antithrombin 1x25IU:

Catalog # 81079639
Packaging Vial/25IU
Method Chromogenic
Type Bioreagent
Use For Research Use Only
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Chromogenix Antithrombin 25IUis a lyophilized powder prepared from human plasma after affinity chromatography on heparin-Sepharose gel. For the determination of Heparin. Pure preparation, does not contain stabilizer. Albumin-free.

Each vial contains:

  • Lyophilized human Antithrombin 25 – 30 lU
  • Sodium Chloride 11 mg
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FACTOR XA 10X71 nkat:

Catalog # 82098539
Packaging Vial/71nkat
Method Chromogenic
Type Bioreagent
Use Research Use Only (RUO)
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Description

Chromogenic Factor Xa 71 nkat, is for the determination of Heparin in plasma. Factor X is purified from a barium cytrate elution of bovine plasma and it is activated to FXa by a Russell’s Viper Venom matrix.

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Chromogenix S-2238™

Catalog # 82032439
Packaging Vial/25mg
Method Chromogenic
Type Substrate
Use For Research Use Only
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Chromogenix S-2238™ is a chromogenic substrate for thrombin. The substrate has been used for the determination of:

  • Prothrombin in plasma
  • Antithrombin in plasma
  • Platelet factor 3 in plasma
  • Heparin in plasma

Each vial contains chromogenic substrate S-2238™ 25 mg and mannitol 120 mg as a bulking agent. Stability: Substance: Stable until expiry date if stored at 2-8°C. Avoid exposure to light. The substance is hygroscopic and should be stored dry. Solution: 1 mmol/L in H2O is stable for more than 6 months at 2-8°C.

Chemical name: H-D-Phenylalanyl-L-pipecolyl-Larginine-p-nitroaniline dihydrochloride.

pFormula: H-D-Phe-Pip-Arg-pNA·2 HCl

Mol. wt.: 625.6

e316 nm:1.27 . 104 mol-1 . L . cm-1

Solubility: > 10 mmol/L in H2O

Suitable stock solution: 1-2 mmol/L in H2O.

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Chromogenix S-2765™

Catalog # 82141339
Packaging Vial/25mg
Method Chromogenic
Type Substrate
Use For Research Use Only
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Chromogenix S-2765™ is a chromogenic substrate for determination of Factor Xa activity. It is also very sensitive to trypsin. It is suitable for measuring FXa inhibition in heparin anti-Xa assays and antithrombin anti-Xa assays.

Each vial contains the chromogenic substrate S-2765™, 25 mg and mannitol 60 mg as a bulking agent.

Stability: Lyophilized substance: stable at 25°C until expiry date printed on the label. The substance is hygroscopic and should be stored in a dry place.

Solution: 2 mmol/L in H2O is stable for six months at 2 to 8°C. Suitable stock solution: 1-2 mmol/L in H2O.

Chemical name:N-a-Benzyloxycarbonyl-Darginyl-L-glycyl-L-arginine-pnitroaniline-dihydrochloride

Formula:N-a-Z-D-Arg-Gly-Arg-pNA·2HCl

Mol. wt.: 714.6

e316 nm:1.27 . 104 mol-1 . L . cm-1

Solubility: > 10 mmol/L in H2O

Suitable stock solution: 1-2 mmol/L in H2O.

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Chromogenix S-2251™

Catalog # 82033239
Packaging Vial/25mg
Method Chromogenic
Type Substrate
Use For Research Use Only
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Chromogenix S-2251™ is a chromogenic substrate for plasmin and streptokinase-activated plasminogen. The substrate has been used for the determination of:

  • Antiplasmin in plasma
  • Plasminogen in plasma

Each vial contains chromogenic substrate S-2251™, 25 mg and mannitol 60 mg as a bulking agent. Stability: Substance: Stable until expiry date if stored at 2-8°C. Avoid exposure to light. The substance is hygroscopic and should be stored dry. Solution: 3 mmol/L in H2O is stable for at least 6 months at 2-8°C. Contamination by microorganisms may cause hydrolysis.

Chemical name:H-D-Valyl-L-leucyl-L-lysinep-Nitroaniline dihydrochloride

Formula:H-D-Val-Leu-Lys-pNA · 2HCl

Mol. wt.: 551.6

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Chromogenix S-2302™

Catalog # 82034039
Packaging Vial/25mg
Method Chromogenic
Type Substrate
Use For Research Use Only
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Chromogenix S-2302™ is a chromogenic substrate for plasma kallikrein. The substrate has been used for the determination of:

  • Prekallikrein in plasma
  • Kallikrein inhibitors in plasma
  • FXII in plasma
  • Kallikrein-like activity in plasma
  • Prekallikrein activator in albumin and immunoglobulin preparations

Each vial contains chromogenic substrate S-2302™ 25 mg and mannitol 60 mg as a bulking agent. Stability: Substance: Stable until expiry date if stored at 2-8°C. Avoid exposure to light. The substance is hygroscopic and should be stored dry. Solution: 4 mmol/l in H2O is stable for more than 6 months at 2-8°C.

Chemical name:H-D-Prolyl-L-phenylalanyl-Larginine-p-nitroaniline dihydrochloride.

Formula:H-D-Pro-Phe-Arg-pNA·2HCl

Mol. wt.:611.6

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Chromogenix S-2222™

Catalog # 82031639
Packaging Vial/25mg
Method Chromogenic
Type Substrate
Use For Research Use Only
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Chromogenix S-2222™ is a chromogenic substrate for Factor Xa. It is also very sensitive to trypsin. The substrate has been used for the determination of:

  • Factor X in plasma
  • Factor Xa in plasma
  • Factor Xa inhibitor in plasma
  • Heparin in plasma
  • Factor VIII in plasma
  • Coagulating enzyme from horseshoe crab plasma
  • Trypsin in duodenal fluid
The substrate is also sensitive to subtilisin, acrosin and Factor XIIa but insensitive to most other enzymes tested, e.g. Factor IXa, kallikrein (glandular and plasma) and papain-like enzymes.

Each vial contains chromogenic substrate S-2222™ 25 mg and mannitol 120 mg as a bulking agent.

Molecular wt: 741.3

Chemical name:N-Benzoyl-L-isoleucyl-L-glutamyl-glycyl-Larginine-p-nitroaniline hydrochloride and its methyl ester

Formula:Bz-Ile-Glu(g-OR)-Gly-Arg-pNA·HCl R=H (50%) and R=CH3 (50%)

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Chromogenix S-2288™

Catalog # 82085239
Packaging Vial/25mg
Method Chromogenic
Type Substrate
Use For Research Use Only
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Chromogenix S-2288™ is a chromogenic substrate sensitive to a broad spectrum of serine proteases. The substrate has been used for the determination of Tissue Plasminogen Activator in purified preparations.

Each vial contains chromogenic substrate S-2288™, 25 mg and mannitol 40 mg as a bulking agent. Stability: Substance: Stable until expiry date if stored at 2-8°C. Avoid exposure to light. The substance is hygroscopic and should be stored in a dry place. Solution: 10 mmol/L in H2O is stable for more than two months at 2-8°C.

Chemical name:H-D-Isoleucyl-L-prolyl-L-arginine-pnitroaniline dihydrochloride.

Formula:H-D-lle-Pro-Arg-pNA · 2HCl

Mol. wt: 577.6

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Chromogenix S-2366™

Catalog # 82109039
Packaging Vial/25mg
Method Chromogenic
Type Substrate
Use For Research Use Only
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Description

Chromogenix S-2366™ is a chromogenic substrate for factor XI and activated protein C. The substrate can be used for the determination of purified enzyme preparations as well as of Protein C and FXI in plasma.

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Chromogenix S-2403™

Catalog # 82225439
Packaging Vial/25mg
Method Chromogenic
Type Substrate
Use For Research Use Only
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Chromogenix S-2403™ is a chromogenic substrate for plasmin and streptokinase-activated plasminogen.

Each vial contains the chromogenic substrate S-2403™ 25 mg and mannitol 60 mg as a bulking agent. Stability: Substance: Stable until expiry date if stored at 2-8°C. Avoid exposure to light. The substance is hygroscopic and should be stored dry. Solution: 7.5 mmol/L in H2O is stable for at least 6 months at 2 to 8°C.

Chemical name:L-Pyroglutamyl-L-Phenylalanyl-L-Lysine-p-Nitroaniline hydrochloride.

Mol. wt: 561.0

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COAMATIC FACTOR VIII:

Catalog # 82258563
Packaging Kit/120 tests
Method Chromogenic
Type Kit
Use IVD
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Description

Chromogenix Coamatic® Factor VIII is a chromogenic assay kit for the photometric determination of factor VIII activity in plasma, such as when identifying factor VIII deficiency or monitoring patients on replacement therapy as well as for potency estimation of FVIII concentrates. This Factor VIII test kit fulfills the requirements of the European Pharmacopoeia for factor VIII concentrate testing. Co-lyophilization of reagents for convenient handling. Reliable tool for hemophilia classification. No interference from heparin levels up to 1.5 IU/ml. The Factor VIII kit has two measuring ranges.

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COAMATIC HEPARIN:

Catalog # 82339363
Packaging Kit/200 tests
Method Chromogenic
Type Kit
Use IVD
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Chromogenix Coamatic® Heparin is a chromogenic assay kit for the quantitative determination of unfractionated heparin (UF Heparin) or low molecular weight heparin (LMW Heparin) in human citrated plasma using automated and microplate methods.

Reagents, Packaging, Storage, Stability The sealed reagents are stable at 2-8°C until the expiry date printed on the label.

S-2732™, 15 mg,2 vials. Chromogenic substrate, Suc-Ile-Glu(-pip)-Gly-Arg-pNA·HCl lyophilized with detergent and mannitol as bulking agent. Stability after reconstitution: 3 months at +2-8°C in the original vial. Avoid exposure to light. Discard the substrate solution if it appears yellow. Avoid contamination by microorganisms.

Factor Xa, 35 nkat,2 vials. Lyophilized bovine FXa containing Tris buffer, EDTA, NaCl, dextran sulfate and bovine serum albumin. Stability after reconstitution: 3 months at +2-8°C in the original vial.

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COATEST HEPARIN:

Catalog # 25553963
Packaging Kit/400 tests
Method Chromogenic
Type Kit
Use IVD
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Chromogenix Coatest® Heparin is a chromogenic assay kit for the in vtiro diagnostic photometric determination of heparin in human plasma. The Coatest® Heparin test kit determines the anti-FXa activity of LMW heparin and UF heparin. Excellent reagent stability. Suitable for both large and small laboratories.

Reagents, Packaging, Storage, Stability, and Microplate/Test Tube Preparation

  • S-2222™, 1 vial. Chromogenic substrate (Bz-IIe-Glu-(g-OR)-Gly-Arg-pNA·HCl) 15 mg with mannitol added as a bulking agent. Reconstitute with 20 mL sterile water to obtain a concentration of 1 mmol/l. The solution is stable for 6 months at 2-8°C.
  • Factor Xa, 1 vial. Bovine Factor Xa 71 nkat. Reconstitute with 10 mL sterile water. The reconstituted Factor Xa is stable for 1 month at 2-8°C or 6 months at -20°C or below.
  • Buffer, stock solution, 1 vial. Tris 0.5 mol/l, pH 8.4, 10 ml. An opened vial of stock solution is stable for 2 months at 2-8°C. Before use dilute accordingly: 1 volume of stock solution with 9 volumes of sterile water.
  • Antithrombin, 1 vial. Lyophilized human Antithrombin, 10 IU. Reconstitute with 10 mL sterile water to obtain a concentration of 1 IU/ml. The reconstituted Antithrombin is stable for 1 month at 2-8°C or 6 months at -20°C or below.
  • Normal Plasma (human), 4 vials. Lyophilizied plasma. Reconstitute with 1.00 mL sterile water. The reconstituted plasma is stable for two weeks at 2-8°C or 1 month at -20°C or below.

When kept at 2-8°C the sealed reagents are stable until expiry date printed on the label. Avoid contamination by microorganisms in opened vials.

PRODUCT INFORMATION
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COATEST SP FACTOR VIII:

Catalog # 82408663
Packaging Kit/200 tests
Method Chromogenic
Type Kit
Use IVD
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Chromogenix Coatest® SP Factor VIII is a chromogenic assay kit for the in vitro diagnostic photometric determination of factor VIII activity in citrated plasma, such as when identifying factor VIII deficiency or monitoring patients on replacement therapy, as well as for potency estimation of FVIII concentrates. This factor VIII test kit has two measuring ranges plus validated and documented protocols for a wide range of instruments.

Reagents, Packaging, Storage, Stability, and Microplate/Test Tube Preparation

  • S-2765™ 15.4 mg + I-2581, 1 vial. Chromogenic substrate (N-a-Z-D-Arg-Gly-Arg-pNA), 15.4 mg, synthetic thrombin inhibitor, 0.4 mg, and mannitol added as a bulking agent. Reconstitute with 12.0 mL of sterile water or NCCLS type II water, to obtain a concentration of 1.8 mmol/L. Stability after reconstitution: 3 months at 2-8°C.
  • Factor IXa + factor X 9.2 IU, 1 vial. Lyophilized bovine factors IXa and X with bovine albumin added as a stabilizing agent. Reconstitute with 10.0 mL of sterile water or NCCLS type II water. Stability after reconstitution: 12 hours at 2-8°C. The solution can be stored frozen in aliquots at -20°C (or at lower temperature) for 3 months. Do not refreeze.
  • CaCl2 6 ml, 1 vial. Calcium chloride solution, 0.025 mol/L Ready to use. Opened vial is stable 3 months at 2-8°C.
  • Buffer, stock solution 20 mL,1 vial. 20 mL concentrated Tris buffer containing NaCl and BSA. Characteristics of tenfold diluted buffer: Tris 0.05 mol/L, pH 7.3, 10 mg/L Ciprofloxacin and 1.0% BSA. Dilute 1:10 (1+9) with sterile water or NCCLS type II water. Prepare a new buffer working solution each day. Once opened the buffer is stable 3 months at 2-8°C.
  • Phospholipid 2 mL, 1 vial. Mixture of highly purified phospholipids and 10 mg/L Ciprofloxacin. Ready to use. When kept at 2-8°C the sealed reagents are stable until the expiry date printed on the label.
PRODUCT INFORMATION
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COATEST SP4 FACTOR VIII:

Catalog # 82409463
Packaging Vial/5mg
Method Chromogenic
Type Substrate
Use Invitro Diagnostics
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Chromogenix Coatest® SP Factor VIII is a chromogenic assay kit for the in vitro diagnostic photometric determination of factor VIII activity in citrated plasma, such as when identifying factor VIII deficiency or monitoring patients on replacement therapy, as well as for potency estimation of FVIII concentrates. This factor VIII test kit has two measuring ranges plus validated and documented protocols for a wide range of instruments.

Reagents, Packaging, Storage, Stability, and Microplate/Test Tube Preparation

  • S-2765™ 15.4 mg + I-2581,1 vial. Chromogenic substrate (N-a-Z-D-Arg-Gly-Arg-pNA), 15.4 mg, synthetic thrombin inhibitor, 0.4 mg, and mannitol added as a bulking agent. Reconstitute with 12.0 mL of sterile water or NCCLS type II water, to obtain a concentration of 2.7 mmol/L. Stability after reconstitution: 3 months at 2-8°C.
  • Factor IXa + factor X 2.7 IU, 4 vials. Lyophilized bovine factors IXa and X with bovine albumin added as a stabilizing agent. Reconstitute with 3.0 mL of sterile water or NCCLS type II water. Stability after reconstitution: 12 hours at 2-8°C. The solution can be stored frozen in aliquots at -20°C (or at lower temperature) for 3 months. Do not refreeze.
  • CaCl2 6 ml, 1 vial. Calcium chloride solution, 0.025 mol/L Ready to use. Opened vial is stable 3 months at 2-8°C.
  • Buffer, stock solution 20 mL,1 vial. 20 mL concentrated Tris buffer containing NaCl and BSA. Characteristics of tenfold diluted buffer: Tris 0.05 mol/L, pH 7.3, 10 mg/L Ciprofloxacin and 1.0% BSA. Dilute 1:10 (1+9) with sterile water or NCCLS type II water. Prepare a new buffer working solution each day. Once opened the buffer.
  • Phospholipid 2 mL,1 vial. Mixture of highly purified phospholipids and 10 mg/L Ciprofloxacin. Ready to use. Opened vial is stable for 3 months at 2-8°C. Shake gently before use. When kept at 2-8°C the sealed reagents are stable until the expiry date printed on the label. Contamination by microorganisms should be avoided once the vials are opened.
PRODUCT INFORMATION
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